Erdj5/DNAJC10蛋白抗体
规格：1mg/1ml
英文名： DNAJC10
别名： DNAJC10; DnaJ (Hsp40) homolog subfamily C member 10; DnaJ homolog subfamily C member 10; DNAJC 10; ER resident protein ERdj5; ERdj 5; ERdj5; J domain containing protein disulfide isomerase like protei
分子量： 88kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DNAJC10
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
细胞定位：
Erdj5/DNAJC10蛋白抗体产品介绍：background: This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been Erdj5/DNAJC10蛋白抗体observed for this gene. [provided by RefSeq, Oct 2012]. Function: This endoplasmic reticulum co-chaperone may play a role in protein folding and translocation across the endoplasmic reticulum membrane. May act as a co-chaperone for HSPA5. Subunit: Interacts with HSPA5 via its J domain. Subcellular Location: Secreted (Potential). Endoplasmic reticulum lumen. Similarity: Contains 1 J domain. Contains Erdj5/DNAJC10蛋白抗体4 thioredoxin domains. Gene ID: 54431 Database links: Entrez Gene: 54431 Human Omim: 607987 Human SwissProt: Q8IXB1 Human Unigene: 516632 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. ERdj5酶的功能就像一个“质检员”，能够识别出那些Erdj5/DNAJC10蛋白抗体存在缺陷的蛋白质，并在这些蛋白质“上岗”前将其降解掉。由于降解的是蛋白质，而不是变异本身，因此过降解导致了变异型蛋白质CFTR降解，出现囊肿性纤维化病理改变（如：遗传性胰腺**）。
产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid