DNA交联修复基因SNM1抗体
规格：1mg/1ml
英文名： SNM1
别名： DCLRE1A; DNA cross link repair 1A; DNA cross link repair gene SNM1; PSO2.
分子量： 116kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SNM1
交叉反应：Human,
细胞定位：细胞核
DNA交联修复基因SNM1抗体产品介绍：background: This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] Function: May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.DNA交联修复基因SNM1抗体 Subunit: Binds constitutively to TP53BP1. Binds CDC27, which is itself a component of the anaphase promoting complex (APC). Binds PIAS1. Subcellular Location: Nuclear. Tissue Specificity: Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle. DISEASE: In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1.DNA交联修复基因SNM1抗体 Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11A, RAD50 and NBN) and BRCA1. Similarity: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family. Database links: Entrez Gene: 9937 Human Omim: 609682 Human SwissProt: Q6PJP8 Human Unigene: 1560 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
DNA交联修复基因SNM1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞周期蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid