蔗糖非发酵蛋白SNF2H抗体
规格：1mg/1ml
英文名： SNF2H
别名： 4933427E24Rik; ATP-dependent chromatin remodeling protein SNF2H; D030040M08Rik; D330027N15Rik; EC 3.6.1.-; hISWI; hSNF2H; ISWI; MommeD4; SMARCA5; SMCA5; SMCA5_HUMAN; Snf2h; Sucrose nonfermenting like
分子量： 122kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SNF2H
交叉反应：Human, Mouse, Rat, Dog, Rabbit, Guinea Pig,
细胞定位：细胞核
蔗糖非发酵蛋白SNF2H抗体产品介绍：background: The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. [provided by RefSeq, Jul 2008] Function: Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication蔗糖非发酵蛋白SNF2H抗体 of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. Subcellular Location:蔗糖非发酵蛋白SNF2H抗体 Nucleus. Tissue Specificity: Ubiquitously expressed. DISEASE: Developmental stage; Overexpressed in CD34-positive erythrocyte progenitor cells in acute myeloid leukemia. Down-regulation correlates with hematologic remission following chemotherapy. Similarity: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 2 SANT domains. Database links: Entrez Gene: 8467 Human Entrez Gene: 93762 Mouse Entrez Gene: 307766 Rat Omim: 603375 Human SwissProt: O60264 Human SwissProt: Q91ZW3 Mouse Unigene: 558422 Human Unigene: 246803 Mouse Unigene: 474173 Mouse Unigene: 128772 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蔗糖非发酵蛋白SNF2H抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid