SMG5蛋白抗体
规格：1mg/1ml
英文名： SMG5
别名： EST1-like protein B; EST1B; LPTS-interacting protein; LPTS-RP1; nonsense mediated mRNA decay factor.
分子量： 140kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SMG5
交叉反应：Human, Mouse,
细胞定位：细胞核 细胞浆
SMG5蛋白抗体产品介绍：background: SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]).[supplied by OMIM, Mar 2008] Function: Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for SMG5蛋白抗体TERT activity. Subunit: Interacts with TERT, PPP2CA and SMG1. Part of a complex that contains SMG1, SMG5, SMG7, PPP2CA, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated UPF1. Not detected in complexes thatSMG5蛋白抗体 contain unphosphorylated UPF1. Subcellular Location: Cytoplasmic and Nuclear. Tissue Specificity: Ubiquitous. Similarity: Contains 1 PINc domain. Database links: Entrez Gene: 23381 Human Entrez Gene: 229512 Mouse Omim: 610962 Human SwissProt: Q9UPR3 Human SwissProt: Q6ZPY2 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SMG5蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid