Pellino 2蛋白抗体
规格：1mg/1ml
英文名： Pellino 2
别名： E3 ubiquitin-protein ligase pellino homolog 2; PELI2; pellino E3 ubiquitin protein ligase family member 2; Pellino homolog 2.
分子量： 46kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Pellino
交叉反应：Human, Mouse,
细胞定位：细胞核
Pellino 2蛋白抗体产品介绍：background: Scaffold protein which probably links Toll like receptors (TLRs) to basic cellular processes via its interaction with the complex containing IRAK (IL1R associated kinase) kinases and TRAF6. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Not required for NF-kappa-B activation. Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex Pellino 2蛋白抗体containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Subunit: Interacts with TRAF6, IRAK1, IRAK4 and MAP3K7. Pellino 2蛋白抗体Interacts with BCL10; this interaction is impaired by SOCS3 (By similarity). Post-translational modifications: Phosphorylated by IRAK1 and IRAK4 enhancing its E3 ligase activity. Similarity: Belongs to the pellino family. Contains 1 FHA domain. Database links: Entrez Gene: 57161 Human Entrez Gene: 93834 Mouse Omim: 614798 Human SwissProt: Q9HAT8 Human SwissProt: Q8BST6 Mouse Unigene: 296457 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Pellino 2蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞周期蛋白 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid