PDLIM2蛋白抗体
规格：1mg/1ml
英文名： PDLIM2
别名： FLJ34715; MYSTIQUE; OTTHUMP00000162522; OTTHUMP00000205197; OTTHUMP00000205198; OTTHUMP00000205199; OTTHUMP00000205200; OTTHUMP00000205202; OTTHUMP00000205203; PDLI2_HUMAN; Pdlim2; PDZ and LIM domain
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PDLIM2
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse,
细胞定位：细胞核 细胞浆
PDLIM2蛋白抗体产品介绍：background: This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and ***** T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011] Function: Probable adapter protein located at the actin cytoskeleton that promotesPDLIM2蛋白抗体 cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. Subcellular Location: Cytoplasm > cytoskeleton; Nucleus; Cytoplasm. Nucleus. May be partially nuclear and Cytoplasm > cytoskeleton. Colocalizes with beta-1 integrin (ITGB1) and PDLIM2蛋白抗体alpha-actinin but not with paxillin. Similarity: Contains 1 LIM zinc-binding domain. Contains 1 PDZ (DHR) domain. Gene ID: 64236 Database links: Entrez Gene: 64236 Human Entrez Gene: 213019 Mouse Entrez Gene: 290354 Rat Omim: 609722 Human SwissProt: Q96JY6 Human SwissProt: Q8R1G6 Mouse SwissProt: Q6AYD6 Rat Unigene: 632034 Human Unigene: 283968 Mouse Unigene: 105730 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PDLIM2蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 结合蛋白 细胞骨架 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid