载脂蛋白B-mRNA编辑酶复合物3C抗体
规格：1mg/1ml
英文名： APOBEC3C
别名： ABC3C_HUMAN; APOBEC1 like; APOBEC1-like; APOBEC1L; APOBEC3C; Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3C; ARDC2; ARDC4; ARP5; bK150C2.3; MGC19485; PBI; Phorbolin I; Phorbolin I
分子量： 23kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human APOBEC3C
交叉反应：Human,
细胞定位：细胞核 细胞浆
载脂蛋白B-mRNA编辑酶复合物3C抗体产品介绍：background: APOBEC proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22. Like APOBEC3G, APOBEC3F deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, resulting in G to A hypermutation in the plus strand of DNA. Thus, APOBEC3G and APOBEC3F provide a mechanism for innate immunity to retroviruses, and are also likely contribute to sequence variation observed in many viruses. Viral infectivity factor (Vif) imparts APOBEC3G and APOBEC3F resistance to HIV through impaired translation of their mRNA and accelerated posttranslational degradation of the APOBEC3 proteins by the 26S proteasome. Interestingly, 载脂蛋白B-mRNA编辑酶复合物3C抗体HIV-1 Vif cannot form a complex with APOBEC3G or APOBEC3F of mouse origin as it does with the human protein, and thus mouse APOBEC3G and APOBEC3F function as a potent inhibitors of wildtype HIV-1 replication, where human APOBEC3G and APOBEC3F are only able to inhibit Vif-deficient HIV-1 replication. This implies that induction of APOBEC3G and APOBEC3F activity or a method of blocking their interaction with Vif may provide a method for therapeutic intervention. Function: Host cellular restriction factor that may have antiviral activities against 载脂蛋白B-mRNA编辑酶复合物3C抗体exogenous and endogenous viruses, as well as retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Subunit: Homodimer. Interacts with human foamy virus protein Bet; this interaction does not induce APOBEC3C degradation, but prevents dimerization and incorporation into virion of the latter. Interacts with TRIB3 and EIF2C2/AGO2. Subcellular Location: Nucleus. Cytoplasm. Tissue Specificity: Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary. Similarity: Belongs to the cytidine and deoxycytidylate deaminase family. Gene ID: 27350 Database links: Entrez Gene: 27350 Human Omim: 607750 Human SwissProt: Q9NRW3 Human Unigene: 441124 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
载脂蛋白B-mRNA编辑酶复合物3C抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid