14-3-3γ抗体
规格：1mg/1ml
英文名： 14-3-3 gamma
别名： 14 3 3 protein gamma; 14 3 3 protein gamma subtype; 14 3 3gamma; 14-3-3 protein gamma; 1433G_HUMAN; 3 monooxygenase/tryptophan 5 monooxgenase activation protein gamma polypeptide; KCIP 1; KCIP-1; KCIP
分子量： 28kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human 14-3-3 g
交叉反应：Human, Mouse, Rat, Dog, Horse, Rabbit, Zebrafish, Sheep,
细胞定位：细胞浆
14-3-3γ抗体产品介绍：background: 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 b, g, e, z, h, q and s. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins; by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity, and facilitation of protein modification. Loss of expression contributes to a vast array 14-3-3γ抗体of pathogenic cellular activities. Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Subunit: Homodimer. Interacts with SAMSN1 (By similarity). Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with PKA-phosphorylated AANAT. Subcellular Location: Cytoplasm.14-3-3γ抗体 Tissue Specificity: Highly expressed in brain, skeletal muscle, and heart. Post-translational modifications: Phosphorylated by various PKC isozymes. Similarity: Belongs to the 14-3-3 family. Gene ID: 7532 Database links: Entrez Gene: 7532 Human Entrez Gene: 22628 Mouse Entrez Gene: 56010 Rat Omim: 605356 Human SwissProt: P61981 Human SwissProt: P61982 Mouse SwissProt: P61983 Rat Unigene: 721582 Human Unigene: 233813 Mouse Unigene: 482082 Mouse Unigene: 29936 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
14-3-3γ抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导 干细胞 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid