分选连接蛋白6抗体
规格：1mg/1ml
英文名： SNX6
别名： Sorting Nexin 6; TFAF2; TRAF4 Associated Factor 2; SNX6_HUMAN.
分子量： 47kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SNX6
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆 细胞膜
分选连接蛋白6抗体产品介绍：background: Two related proteins, TRAF1 and TRAF2 (TNF receptor-associated factors 1 and 2, respectively), form a heterodimeric complex that associates with the cytoplasmic domain of the tumor necrosis factor (TNF) receptor type 2 (1). A third member of this family, TRAF3 (also designated CD40bp or CRAF1) associates with the cytoplasmic domain of CD40 (2). Additional membersof the TRAF/CRAF family of signaling intermediates include TRAF4 (also designated CART1), TRAF5 and TRAF6 (3-5). TRAF4 associated factor 2 (TRAF4-AF2), also designated sorting nexin 6 (SNX6), is a member of the sorting nexin family of molecules, which are widely expressed and associate with various receptor (6). Function: Snx6 is a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is 分选连接蛋白6抗体a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. Subunit: Interacts with CDKN1B (By similarity)分选连接蛋白6抗体. Interacts with TGFB receptors. Interacts with dynactin subunit DCTN1. Interacts with SNX1 and SNX2. Interacts with BACE1 and BRMS1. Subcellular Location: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Nucleus. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes. Only a minor proportion is seen in the nucleus. Similarity: Belongs to the sorting nexin family. Contains 1 PX (phox homology) domain. Database links: UniProtKB/Swiss-Prot: Q9UNH7.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
分选连接蛋白6抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 干细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid