B**细胞基因1抗体
规格：1mg/1ml
英文名： TLE4
别名： B lymphocyte gene 1; B lymphocyte gene 1; enhancer of split groucho 4; enhancer of split groucho 4; ESG4; ESG4; KIAA1261; TIM; TIM1; timeless (Drosophila) homolog; TLE4; transducin-like enhancer of sp
分子量： 84kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TLE4
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞核
B**细胞基因1抗体产品介绍：background: The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervical squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. B**细胞基因1抗体TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is upregulated, and TLE2 and TLE4 are downregulated. In later stages, TLE2 and TLE4 are upregulated, and expression of TLE1 decreases. Function: TLE4 (Transducin-like enhancer protein 4) is a member of the Groucho family of transcriptional corepressors and inhibits the transcriptional activation mediated by Pax5 and by beta-catenin and TCF family members in Wnt signaling. Subunit: Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2. Interacts with ZNF703; B**细胞基因1抗体TLE4 may mediate ZNF703 transcriptional repression (By similarity). Subcellular Location: Nuclear Tissue Specificity: In all tissues examined, mostly in brain, and muscle. Post-translational modifications: Phosphorylated. PAX5 binding increases phosphorylation (By similarity). Ubiquitinated by XIAP/BIRC4. Similarity: Belongs to the WD repeat Groucho/TLE family. Contains 7 WD repeats. Database links: UniProtKB/Swiss-Prot: Q04727.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
B**细胞基因1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 染色质和核信号 神经生物学 信号转导 干细胞 转录调节因子 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid