G蛋白偶联诱导蛋白2受体抗体
规格：1mg/1ml
英文名： TRIB1
别名： Tribbles homolog 1; TRB-1; G-protein-coupled receptor-induced gene 2 protein; GIG-2; SKIP1; TRIB1_HUMAN; C8FW; GIG2; TRB1; Trib1; Tribbles homolog 1.
分子量： 41kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from Human TRIB1/GI
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Monkey,
细胞定位：
G蛋白偶联诱导蛋白2受体抗体产品介绍：background: TRB-1 is a 372 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase superfamily. Expressed ubiquitously with highest expression in bone marrow, thyroid gland, skeletal muscle and pancreas, TRB-1 interacts with MAPK kinases and is thought to regulate the activation of MAP kinses, possibly controlling MAP kinase cascades. The gene encoding TRB-1 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies. Function: Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity. Subcellular Location: cytoplasm. Tissue Specificity: Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow. Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr proteinG蛋白偶联诱导蛋白2受体抗体 kinase family. Tribbles subfamily. Contains 1 protein kinase domain. Database links: Entrez Gene: 10221 Human Entrez Gene: 211770 Mouse Entrez Gene: 78969 Rat Entrez Gene: 521857 Cow Omim: 609461 Human SwissProt: Q96RU8 Human SwissProt: Q8K4K4 Mouse Unigene: 444947 Human Unigene: 40298 Mouse Unigene: 204391 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Trib1在脂肪组织维持和脂质代谢紊乱上发挥关键作用; 巨噬细胞至少有两个亚类，即M1型和M2型。M1型巨噬细胞参与促炎反应，且在宿主防御**和病毒感染中发挥核心作用。M2巨噬细胞与**反应、寄生虫感染、组织重构、G蛋白偶联诱导蛋白2受体抗体纤维化以及肿瘤**发展相关。 Trib1是个衔接蛋白，与泛素连接酶COP1相互作用参与蛋白降解。人类全基因组关联研究表明TRIB1参与脂质代谢。 日前，大阪大学WPI**前沿研究中心等处的研究人员，发现Trib1对F4/80 + MR +组织内在巨噬细胞的分化至关重要，且这些巨噬细胞和M2巨噬细胞、酸性粒细胞具有共同的特性(称之为M2类巨噬细胞)。但是，Trib1在M1髓系细胞就不会发挥这种作用。相关研究成果刊登在近期出版的《自然》（Nature）杂志上。 Trib1缺陷导致各种器官中M2类巨噬细胞急剧减少，如骨髓、脾脏、肺以及脂肪组织。在Trib1缺失的骨髓细胞中，C / EBP α的异常表达要为巨噬细胞分化缺陷负责。没有想到的是，造血细胞缺乏 Trib1的小鼠，减少了脂肪组织块，并伴随着脂肪分解增加，即使是在正常饮食条件下。 M2类巨噬细胞的补充可缓解这种病理学现象。这表明，这类巨噬细胞的缺乏是引发脂肪分解的原因。为了应对高脂肪饮食，造血细胞缺乏 Trib1的小鼠发育中会呈现高甘油三酯血症、胰岛素抗性，同时增加促炎细胞基因诱导。 这些结果表明Trib1在脂肪组织维持和脂质代谢紊乱上发挥关键作用，而其作用是通过控制组织内在M2类巨噬细胞的分化实现的。
G蛋白偶联诱导蛋白2受体抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：发育生物学 信号转导 干细胞 细胞凋亡 激酶和磷酸酶 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid