新型分泌细胞表面蛋白/成骨细胞相关蛋白SCUBE3抗体
规格：1mg/1ml
英文名： SCUBE3
别名： CEGF3; CUB and EGF containing protein 3; CUB and EGF-like domain-containing protein 3; CUB domain and EGF like repeat containing 3; DKFZp686B09105; DKFZp686B1223; DKFZp686D20108; FLJ34743; OTTHUMP0000
分子量： 107kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from Human SCUBE3
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞膜 细胞外基质 分泌型蛋白
新型分泌细胞表面蛋白/成骨细胞相关蛋白SCUBE3抗体产品介绍：background: SCUBE3 is a novel secreted 993 amino acid cell-surface osteoblast protein that plays an important role in bone cell biology. While highly expressed in osteoblasts, SCUBE3 expression is unobservable or very low in non-bone tissues. SCUBE3 forms homo-oligomers and hetero-oligomers with SCUBE1, and may undergo C-terminal proteolytic cleavage or become N-glycosylated following translation. Two SCUBE3 isoforms exist as a result of alternative splicing events. SCUBE3 contains one CUB domain and nine EGF-like domains, and is encoded by a gene which maps to human chromosome 6p21.31, a region associated with a rare form of metabolic bone disease known as Paget's disease. Chromosome 6 contains 170 million base pairs and comprises nearly 6% of the human genome. 新型分泌细胞表面蛋白/成骨细胞相关蛋白SCUBE3抗体Function: Binds to TGFBR2 and activates TGFB signaling. In lungcancer cells, could serve as an endogenous autocrine and paracrineligand of TGFBR2, which could regulate TGFBR2 signaling and hencemodulate epithelial-mesenchymal transition and cancer progression. Subunit: Forms homooligomers and heterooligomers with SCUBE1.Interacts with TGFBR2 through the CUB新型分泌细胞表面蛋白/成骨细胞相关蛋白SCUBE3抗体 domain; this interaction doesnot affect TGFB1-binding to TGFBR2. Subcellular Location: Secreted. Cell surface. Tissue Specificity: Highly expressed in osteoblasts. Expression is low or absent in non-bone tissues. Post-translational modifications: N-glycosylated. May undergo proteolytic cleavage in the C-terminal region. Similarity: Contains 1 CUB domain. Contains 9 EGF-like domains. Database links: UniProtKB/Swiss-Prot: Q8IX30.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
新型分泌细胞表面蛋白/成骨细胞相关蛋白SCUBE3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：发育生物学 信号转导 干细胞 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid