B**细胞白血病前体蛋白转录因子1抗体
规格：1mg/1ml
英文名： PBX1
别名： DKFZp686B09108; Homeo box protein PBX1; Homeo box protein PRL; Homeobox protein PBX 1; Homeobox protein PBX1; Homeobox protein PRL; MGC126627; PBX 1; Pbx1; PBX1_HUMAN; Pre B cell leukemia homeobox 1;
分子量： 47kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from Human PBX1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Zebrafish,
细胞定位：细胞核
B**细胞白血病前体蛋白转录因子1抗体产品介绍：background: Pbx 1, 2, 3 and 4 are members of the TALE (three amino acid loop extension) family of homeodomain-containing proteins. Human pre-B cell acute leukemias are frequently associated with a t(1;19)(q23;p13.3) chromosomal rearrangement, which creates a chimeric gene encoding a fusion between the E2A and Pbx 1 gene products. Pbx 2 and Pbx 3 share 92% and 94% respective identities with Pbx 1 over a 266 amino acid region flanking their homeobox domains, while all three proteins are quite divergent at their amino- and carboxy-termini. Two forms of Pbx 1 and Pbx 3 each differ primarily in their carboxy-termini and result from alternative mRNA splicing. Unlike other homeotic selector genes which are expressed transiently during development and differentiation, Pbx gene transcripts are ubiquitously expressed in both fetal and ***** tissues and cell lines. Additionally, Pbx 2 and Pbx 3 transcripts are detected in lymphoid cells, which do not express Pbx 1. Pbx 4 expression is confined to the testis, especially to spermatocytes in the pachytene stage of the first meiotic prophaseB**细胞白血病前体蛋白转录因子1抗体. Function: Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Subunit: Forms a heterodimer with MEIS1 which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterotrimers with MEIS1 and a number of HOX proteins including HOXA9, HOXD4, HOXD9 and HOXD10. Interacts with PBXIP1 and TLX1. B**细胞白血病前体蛋白转录因子1抗体Isoform PBX1a interacts with MEIS2 isoform 4, SP1, SP3 and KLF4. Isoform PBX1b is part of a PDX1:PBX1b:MEIS2b complex; PBX1b recruits Meis2B to the complex. Subcellular Location: Nucleus. Tissue Specificity: Expressed in all tissues except in cells of the B and T lineage. DISEASE: Note=A chromosomal aberration involving PBX1 is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with TCF3. E2A-PBX1 transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members of the PBX protein family. Similarity: Belongs to the TALE/PBX homeobox family. Contains 1 homeobox DNA-binding domain. Database links: UniProtKB/Swiss-Prot: P40424.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
B**细胞白血病前体蛋白转录因子1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 信号转导 干细胞 转录调节因子 **细胞 t-**细胞 b-**细胞 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid