干扰素诱导跨膜蛋白3抗体
规格：1mg/1ml
英文名： Fragilis
别名： 1 8U; Ifitm 3; Ifitm3; IFM3_HUMAN; Interferon induced transmembrane protein 3 (1 8U); Interferon Induced Transmembrane Protein 3; Interferon inducible; Interferon inducible protein 1 8U; Interferon In
分子量： 15kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Fragilis
交叉反应：Human, Mouse, Rat, Cow, Horse,
细胞定位：细胞浆 细胞膜
干扰素诱导跨膜蛋白3抗体产品介绍：background: IFITM3 is a multi-pass membrane protein that belongs to the IFITM (interferon inducible transmembrane) family of proteins. IFITM proteins are induced by type I and type II interferons and contain multiple interferon (IFN)-stimulated response elements (ISREs) in their promoter regions. IFITM proteins play important roles in many cellular processes and their expression requires the presence of the chromatin remodeling SWI/SNF-like BAF complexes. Cellular processes involving IFITM proteins include cellular anti-proliferative activities and homotypic cell adhesion functions of interferons. In addition, IFITM genes are often upregulated in 干扰素诱导跨膜蛋白3抗体various cancer cells, suggesting a possible role in carcinogenesis. Localizing to the membrane, IFITM3 is a 133 amino acid protein that is induced by IFN-?and IFN-? IFITM3 expression can be regulated by TEF-1, Brg-1 and Sp1 Function: IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. Subunit: Interacts with SPP1; the interaction reduces OPN expression. Interacts with ATP6V0B and CD81. Subcellular Location: Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Post-translational modifications: Palmitoylation on membrane-proximal cysteines controls clustering i干扰素诱导跨膜蛋白3抗体n membrane compartments and antiviral activity against influenza virus. Not glycosylated. Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Ubiqutination negatively regulates antiviral activity. Lys-24 is the most prevalent ubiquitination site. Similarity: Belongs to the CD225 family. Database links: Entrez Gene: 10410 Human Entrez Gene: 66141 Mouse Entrez Gene: 361673 Rat Omim: 605579 Human SwissProt: Q01628 Human SwissProt: Q9CQW9 Mouse SwissProt: P26376 Rat Unigene: 374650 Human Unigene: 141021 Mouse Unigene: 145191 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
干扰素诱导跨膜蛋白3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-300 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 干细胞 细胞膜蛋白
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid