锌指蛋白350/乳腺癌易感基因1结合蛋白抗体
规格：1mg/1ml
英文名： ZNF350
别名： KRAB zinc finger protein ZFQR; ZBRK1; ZFQR; Zinc finger and BRCA1 interacting protein with a KRAB domain 1; Zinc finger and BRCA1-interacting protein with a KRAB domain 1; Zinc finger protein 350; Zin
分子量： 60kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from Human ZNF350/Z
交叉反应：Human,
细胞定位：细胞核
锌指蛋白350/乳腺癌易感基因1结合蛋白抗体产品介绍：background: The transcpritional repressor ZBRK1, also designated zinc finger and BRCA1-interacting protein with a KRAB domain 1 or zinc finger protein 350, belongs to the Krüppel C2H2-type zinc-finger protein family of proteins. ZBRK1 localizes mainly to the nucleus and may be associated with the nuclear matrix. It is a widely expressed protein that binds to BRCA1. ZBRK1 plays an important role in transcriptional regulation. Likely targets of gene regulation are DNA damage response genes, which 锌指蛋白350/乳腺癌易感基因1结合蛋白抗体effect the survival and growth control of cells. ZBRK1 contains an N-terminal KRAB domain, a C-terminal BRCA1-binding region and eight central zinc-fingers. Function: Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3. Subunit: Interacts with BRCA1. Interacts with RNF11. Subcellular Location: Nucleus matrix. Associated with the nuclear matrix. Tissue Specificity: Widely expressed. Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 8 C2H2-type zinc 锌指蛋白350/乳腺癌易感基因1结合蛋白抗体fingers. Contains 1 KRAB domain. Database links: Entrez Gene: 59348 Human Entrez Gene: 234358 Mouse Entrez Gene: 100158232 Rat Omim: 605422 Human SwissProt: Q9GZX5 Human Unigene: 407694 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
锌指蛋白350/乳腺癌易感基因1结合蛋白抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 转录调节因子 锌指蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid