APXL蛋白抗体
规格：1mg/1ml
英文名： APXL
别名： Apical like protein; Apical like protein APXL protein; apical protein of Xenopus-like; Apical protein Xenopus laevis like; apical protein, Xenopus laevis-like; apical protein-like; apical protein-like
分子量： 176kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human APXL
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆 细胞膜
APXL蛋白抗体产品介绍：background: APXL is a 1,616 amino acid protein that localizes to a variety of locations within the cell, including the cytoplasm, the cytoskeleton, the cell junction and the apical cell membrane. Containing one ASD1 domain, one ASD2 domain and one PDZ domain, APXL interacts with F-Actin and is thought to mediate endothelial cell morphology during cell spreading, possibly regulating melanosome biogenesis and inducing γ Tubulin redistribution. APXL is expressed in kidney, brain, lung, pancreas and placenta and is overexpressed in melanomas, suggesting a role in tumor transformation and metastasis. The gene encoding APXL maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes. In conjunction with chromosome Y, chromosome X is responsible for sex determination. There are aAPXL蛋白抗体 number of conditions related to an abnormal number and combination of sex chromosomes, some of which include Turner's syndrome, color blindness, hemophilia and Duchenne muscular dystrophy. Function: May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution. Subunit: Interacts with F-actin (By similarity). Subcellular Location: Apical cell membrane (By similarity). Cell junction, tight junction (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associates with cortical F-actin (By similarity). Tissue Specificity: Abundant in APXL蛋白抗体retina and melanoma; also in brain, placenta, lung, kidney and pancreas. Similarity: Belongs to the shroom family. Contains 1 ASD1 domain. Contains 1 ASD2 domain. Contains 1 PDZ (DHR) domain. Gene ID: 357 Database links: Entrez Gene: 357 Human Entrez Gene: 110380 Mouse Entrez Gene: 317435 Rat Omim: 300103 Human SwissProt: Q13796 Human SwissProt: A2ALU4 Mouse SwissProt: Q7TP36 Rat Unigene: 567236 Human Unigene: 40796 Mouse Unigene: 16033 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
APXL蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 神经生物学 通道蛋白 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid