氨基酸转运蛋白2抗体
产品介绍：background: The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family include System A subtypes SNAT1, SNAT2 and SNAT4 and System N subtypes SNAT3 and SNAT5. The SLC38 transporters are essential for the uptake of nutrients, energy production, metabolism, detoxification, and the cycling of neurotransmitters. SNAT2, also designated ATA2, PRO1068 and SAT2 is encoded by the human gene SLC38A2. The functional role of SNAT2 in the nervous system is unclear. Protein expression is notably enriched in the spinal cord and brain stem nuclei of the auditory system. System A transport proteins are also present in placental tissue. These SNAT proteins may play a significant role in fetal development and inhibition of the transport system has been associated with fetal growth retardation. Function: Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry 氨基酸转运蛋白2抗体of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta. Subcellular Location: Cell membrane. Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. Tissue Specificity: Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level). Post-translational 氨基酸转运蛋白2抗体modifications: Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2. Similarity: Belongs to the amino acid/polyamine transporter 2 family. Gene ID: 112483 Database links: Entrez Gene: 338044 Cow Entrez Gene: 54407 Human Entrez Gene: 67760 Mouse Entrez Gene: 29642 Rat Omim: 605180 Human SwissProt: Q96QD8 Human SwissProt: Q8CFE6 Mouse SwissProt: Q9JHE5 Rat Unigene: 221847 Human Unigene: 46754 Mouse Unigene: 16393 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
氨基酸转运蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 通道蛋白 细胞膜受体 转运蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid