烟碱型乙酰胆碱受体α10/AChRα10抗体
规格：1mg/1ml
英文名： CHRNA10
别名： Acetylcholine receptor, neuronal nicotinic, alpha-10 subunit; ACH10_HUMAN; Alpha 10 nAChR; Cholinergic receptor nicotinic alpha 10; Cholinergic receptor, neuronal nicotinic, alpha polypeptide 10; Chol
分子量： 47kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CHRNA10
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
烟碱型乙酰胆碱受体α10/AChRα10抗体产品介绍：background: Members of the ligand-gated ion channel receptor family are characterized by their fast transmitting response to neurotransmitters. Two important members of this family are the nicotinic acetylcholine and glutamate receptors, both of which are composed of five homologous subunits forming a transmembrane aqueous pore. These transmembrane receptors change conformation in response to their cognate neurotransmitter. Nicotinic acetylcholine receptors (AChRs) are found at the postsynaptic membrane of the neuromuscular junction and bind acetylcholine molecules, allowing ions to move through the pore. Glutamate receptors are found in the postsynaptic membrane of cells in the central nervous system. The activity that is generated at the synapse by the binding of acetylcholine is terminated by acetylcholinesterase, an enzyme that rapidly hydrolyzes acetylcholine. ACh Ralpha 10, also known as CHRNA10, is a 450 amino acid烟碱型乙酰胆碱受体α10/AChRα10抗体 multi-pass membrane protein expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes. AChR alpha 10 forms a hetero-oligomeric channels in conjunction with AChR alpha 9 and is considered an ionotropic receptor with a probable role in the modulation of auditory stimuli. Function: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. Subunit: Forms heterooligomeric channels in conjunction with烟碱型乙酰胆碱受体α10/AChRα10抗体 CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 heterooligomers. Subcellular Location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (Probable). Cell membrane; Multi-pass membrane protein (Probable). Tissue Specificity: Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes. Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-10/CHRNA10 sub-subfamily. Gene ID: 57053 Database links: Entrez Gene: 57053 Human Entrez Gene: 504186 Mouse Entrez Gene: 64574 Rat Omim: 606372 Human SwissProt: Q9GZZ6 Human SwissProt: Q9JLB5 Rat Unigene: 157714 Human Unigene: 48767 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
烟碱型乙酰胆碱受体α10/AChRα10抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 通道蛋白 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid