谷氨酸受体红藻氨酸离子2/谷氨酸受体6抗体
规格：1mg/1ml
英文名： GRIK2
别名： CSNB 1B; DKFZp686H1993; EAA4; Excitatory amino acid receptor 4; G protein coupled receptor family C group 1 member F; GLR 6; GLR6; GLUR 6; GluR-6; GLUR6; Glutamate receptor 6; Glutamate receptor; Glut
分子量： 99kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GRIK2/GL
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞膜
产品介绍：background: Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural 谷氨酸受体红藻氨酸离子2/谷氨酸受体6抗体development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate, whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilion 1, 2, 3, 4 and one zeta subunit.谷氨酸受体红藻氨酸离子2/谷氨酸受体6抗体 The zeta subunit is expressed throughout the brainstem, whereas the four epsilon subunits display limited distribution. Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2. Subunit: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers (Probable). Assembles into a kainate-gated homomeric channel that does not bind AMPA. GRIK2 associated to GRIK5 forms functional channels that can be gated by AMPA (By similarity). Interacts with DLG4. Interacts with NETO2 (By similarity). Interacts (via C-terminus) with KLHL17谷氨酸受体红藻氨酸离子2/谷氨酸受体6抗体 (via kelch repeats); the interaction targets GRIK2 for degradation via ubiquitin-proteasome pathway Subcellular Location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Tissue Specificity: Expression is higher in cerebellum than in cerebral cortex. Post-translational modifications: Sumoylation mediates kainate receptor-mediated endocytosis and regulates synaptic transmission. Sumoylation is enhanced by PIAS3 and desumoylated by SENP1. Ubiquitinated. Ubiquitination regulates the GRIK2 levels at the synapse by leading kainate receptor degradation through proteasome. DISEASE: Defects in GRIK2 are the cause of mental retardation autosomal recessive type 6 (MRT6) [MIM:611092]. It is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic mental retardation. MRT6 patients display mild to severe mental retardation and psychomotor development delay in early childhood. Patients do not have neurologic problems, congenital malformations, or facial dysmorphism. Body height, weight, and head circumference are normal. Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 subfamily. Database links: Entrez Gene: 2898 Human Entrez Gene: 14806 Mouse Entrez Gene: 54257 Rat Omim: 138244 Human SwissProt: Q13002 Human SwissProt: P39087 Mouse SwissProt: P42260 Rat Unigene: 98262 Human Unigene: 332838 Mouse Unigene: 87696 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
谷氨酸受体红藻氨酸离子2/谷氨酸受体6抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 通道蛋白 细胞膜受体 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid