Toll样受体5抗体
规格：1mg/1ml
英文名： TLR5
别名： toll-like receptor 5; FLJ10052; MGC126430; MGC126431; TIL 3; TIL3; TLR 5; Toll like receptor 5; Toll like receptor 5 precursor; Toll/interleukin 1 receptor like protein 3;CD285; TLR5_MOUSE.
分子量： 95kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse TLR5
交叉反应：Human, Mouse, Rat,
细胞定位：
Toll样受体5抗体产品介绍：background: The Toll like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin 1 receptor-associated kinase (IRAK) signaling pathway. Toll-like receptor 5 (TLR5) expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Gram-negative bacteria, stimulate monocyte/macrophage cells in a TLR5-specific, CD14-independent manner. The TLR5 receptor thus appears to be the principal means by which the innate immune system recognizes flagellated bacterial pathogensToll样受体5抗体. Function: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Subunit: Homodimer both in the absence and presence of ligand. Binds MYD88 via their respective TIR domains (By similarity). Subcellular Location: Membrane; Single-pass type I membrane protein (By similarity). Tissue Specificity: Highly expressed in liver. Detected in lung and at very low levels in most other tissues.Toll样受体5抗体 Post-translational modifications: Phosphorylated at Tyr-799 upon flagellin binding; required for signaling (By similarity). Similarity: Belongs to the Toll-like receptor family. Contains 16 LRR (leucine-rich) repeats. Contains 1 TIR domain. Gene ID: 53791 Database links: Entrez Gene: 7100 Human Entrez Gene: 53791 Mouse Omim: 603031 Human SwissProt: O60602 Human SwissProt: Q9JLF7 Mouse Unigene: 604542 Human Unigene: 116894 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Toll样受体5可在单核细胞、未成熟树突状细胞及上皮细胞表达 ,可能是一种参与**应答的受体 ,其具体作用尚不清楚。 TLR5可辨认鞭毛蛋白(fla-gellin),此种蛋白可组成鞭毛,与**泳动有关.
Toll样受体5抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 信号转导 细胞膜受体 **及病毒
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid