蛋白酶活化受体4抗体
规格：1mg/1ml
英文名： PAR4
别名： protease-activated receptor 4; 2310001G03Rik; PAR 4; Par4 induced by effectors of apoptosis; PAWR; PRKC Apoptosis WT1 Regulator; PRKC apoptosis WT1 regulator protein; Prostate apoptosis response 4 pro
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PAR4
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig,
细胞定位：细胞膜
蛋白酶活化受体4抗体产品介绍：background: The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008] Function: Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed, with highest levels in 蛋白酶活化受体4抗体lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets. Post-translational modifications: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 5074 Database links: Entrez Gene: 5074 Human Entrez Gene: 114774 Mouse 蛋白酶活化受体4抗体Entrez Gene: 64513 Rat Omim: 601936 Human SwissProt: Q96IZ0 Human SwissProt: Q925B0 Mouse SwissProt: Q62627 Rat Unigene: 643130 Human Unigene: 391419 Mouse Unigene: 9127 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 蛋白酶活化受体-4(前列腺细胞凋亡反应蛋白4)是蛋白酶活化受体PARs (protease-activated receptors , PARs)的成员之一，PAR4在激活、灭活、**、复敏、及其与信号转导途径的关系,尤其是与**的关系正倍受关注。 PAR4具有广泛的生物学效应,*终影响细胞的形态的改变、分泌蛋白和整合蛋白的活化、代谢反应、转录过程和细胞运动，由此参与细胞的信号转导作用。
蛋白酶活化受体4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid