钠离子肌醇转运蛋白抗体
规格：1mg/1ml
英文名： SLC5A3
别名： Na(+)/myo inositol cotransporter; Na(+)/myo-inositol cotransporter; SC5A3_HUMAN; SLC5A3; SMIT; SMIT2; sodium/myo inositol cotransporter 1; Sodium/myo inositol cotransporter; Sodium/myo-inositol cotran
分子量： 80kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SLC5A3/S
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞膜
钠离子肌醇转运蛋白抗体产品介绍：background: Myo-inositol is involved in many important aspects of cellular regulation including membrane structure, signal transduction and osmoregulation. It is taken up into cells by the sodium/myo-inositol cotransporter (SMIT). SMIT activity maintains intracellular concentrations of myo-inositol; it is upregulated in response to hypertonic stress. The human SMIT protein is encoded by the SLC5A3 gene, which maps to chromosome 21q22.12. It is expressed in many human tissues, such as brain, kidney and placenta. Specifically,钠离子肌醇转运蛋白抗体 SMIT is abundantly expressed throughout the whole brain and spinal cord in fetal rat, but is downregulated in ***** rat brain with the exception of the choroid plexus, where SMIT expression remains high. In kidney, SMIT localizes to the baso-lateral membranes of the thick ascending limb of Henle (TAL) and the inner medullary collecting duct (IMCD). Impaired SMIT activity is implicated in the pathogenesis of diabetes and Down syndrome. Function: Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of 钠离子肌醇转运蛋白抗体cellular function. Subcellular Location: Membrane; Multi-pass membrane protein. Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. Database links: Entrez Gene: 6526 Human Omim: 600444 Human SwissProt: P53794 Human Unigene: 302742 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钠离子肌醇转运蛋白抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 神经生物学 信号转导 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid