β1,3-N-乙酰糖基转移酶抗体
规格：1mg/1ml
英文名： Radical Fringe
别名： 3-N-acetylglucosaminyltransferase radical fringe; Beta-1; Beta-1,3-N-acetylglucosaminyltransferase radical fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; RFNG; RFNG_HUMAN.
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Radical
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 细胞膜
β1,3-N-乙酰糖基转移酶抗体产品介绍：background: Three mammalian fringe family members, Manic, Radical and Lunatic Fringe, have been identified as proteins related to Drosophila Fringe, a protein involved in development. Fringe proteins act upstream of the Notch signaling pathway and are involved in boundary determination during segmentation. Each mammalian Fringe displays different patterns of expression, though all are expressed in the mouse embryo as well as in many ***** tissues. Radical Fringe, also known as Beta-1,3-N-acetylglucosaminyltransferase Radical Fringe, is a 331 amino acid single-pass type II membrane protein that localizes to the membrane of the Golgi apparatus. Playing a key role in the β1,3-N-乙酰糖基转移酶抗体development of the limb bud, Radical Fringe transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor. Lunatic Fringe is required for normal somite segmentation and patterning and is thought to be a target of the molecular clock. Manic Fringe, also involved in somatic development, has been shown to render mouse NIH/3T3 cells tumorigenic in SCID mice. Function: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. May be involved in limb formation and in neurogenesis. Subcellular Location: Golgi apparatus membrane; Single-pass type II membrane β1,3-N-乙酰糖基转移酶抗体protein (Potential). Similarity: Belongs to the glycosyltransferase 31 family. Gene ID: 5986 Database links: Entrez Gene: 5986 Human Entrez Gene: 19719 Mouse Entrez Gene: 60433 Rat Omim: 602578 Human SwissProt: Q9Y644 Human SwissProt: O09009 Mouse SwissProt: Q9R1U9 Rat Unigene: 569700 Human Unigene: 871 Mouse Unigene: 168817 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
β1,3-N-乙酰糖基转移酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 干细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid