白介素-23抗体
规格：1mg/1ml
英文名： IL-23
别名： IL 23; IL 23A; IL23P19; Interleukin 23 alpha subunit p19; JKA3 induced upon T cell activation; P19; SGRF; IL-23 subunit alpha; IL-23-A; IL-23p19; IL23; Il23a; IL23A_HUMAN; Interleukin 23 p19 subunit;
分子量： 21kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IL-23
交叉反应：Human, Mouse, Rat,
细胞定位：分泌型蛋白
白介素-23抗体产品介绍：background: IL23 is a heterodimeric cytokine consisting in two subunits : p40, shared with IL12 and a distinct one p19 (the IL23 subunit). Although IL12 activates naive T cells, the initial description of IL23 was the preferential action on memory T cells to increase IFNg production. In conjunction with IL6 and TGF-beta1, IL23 is necessary to maintain the Th1 lineage. IL23 plays an important role in the inflammatory response against infection, and is implicated in the development of cancerous tumors and auto immune diseases. Over expression of p19 correlates with inflammation in multiple organs and epithelial tissues including skin. Function: Associates with IL12B to form the白介素-23抗体 IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Subcellular白介素-23抗体 Location: Secreted. Secreted upon association with IL12B. Tissue Specificity: Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). Similarity: Belongs to the IL-6 superfamily. Gene ID: 51561 Database links: Entrez Gene: 51561 Human Entrez Gene: 83430 Mouse Omim: 605580 Human SwissProt: Q9NPF7 Human SwissProt: Q9EQ14 Mouse Unigene: 382212 Human Unigene: 98309 Human Unigene: 125482 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. IL23(Interleukin-23)作为一种前炎症细胞因子，具有影响机体**反应和抗感染作用,白介素23能连接肿瘤关联的炎症和肿瘤**监督缺乏关系的细胞因子。存在于很多人类肿瘤中，能通过促进血管形成来帮助肿瘤生长。
白介素-23抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid