核糖核酸结合蛋白2抗体
规格：1mg/1ml
英文名： PTBP2
别名： brPTB; FLJ34897; MIBP; Neural polypyrimidine tract binding protein; Neurally enriched homolog of PTB; Polypyrimidine tract binding protein 2; PTB; PTB like; PTB like protein; PTBLP; PTBP 2; PTBP-2; Sp
分子量： 57kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PTBP2
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Zebrafish, Sheep,
细胞定位：细胞核
核糖核酸结合蛋白2抗体产品介绍：background: PTBP-2 is a member of the polypyrimidine tract binding family of proteins. Predominantly expressed in brain, but also found in heart and skeletal muscle, PTBP-2 localizes to the nucleus and contains four RRM (RNA recognition motif) domains. PTBP-2 functions as an RNA-binding protein associated in a complex that is involved in the regulation of exon splicing and the stabilization of mRNAs in the cytoplasm. Six isoforms exist for PTBP-2 due to alternative splicing events. Isoforms 1 and 2 (also known as nPTB1 and nPTB2/PTBPLP-L, respectively) are neuronal-specific. Isoforms 3 and 4 (also known as nPTB3/PTBPLP-L and nPTB4, respectively) are found in non-neuronal tissues, as are isoforms 5 and 6 (also known as nPTB5/nPTB7/PTBPLP-S and nPTB6/nPTB8/PTBPLP-S, respectively). The existence of核糖核酸结合蛋白2抗体 various isoforms may function to modulate the RNA-binding properties of PTBP-2 Function: PTPBP2 is an RNA-binding protein which binds to intronic polypyrimidine tracts. It binds to the CUCUCU splicing repressor element of the downstream control sequence (DCS) and mediates negative regulation of exons splicing. It may also have a role in the regulation of translation. PTBP2 is thought to be involved in the switch to neuronal specific alternative splicing patterns during neuronal differentiation. Subunit: Monomer. Interacts with NOVA1; the interaction is direct. Interacts with NOVA2; the interaction is direct (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Part of a ternary complex containing KHSRP and HNRPH1. Subcellular Location: Nuclear Tissue Specificity: Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically 核糖核酸结合蛋白2抗体expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non-neuronal tissues. Similarity: Contains 4 RRM (RNA recognition motif) domains. Gene ID: 58155 Database links: Entrez Gene: 58155 Human Entrez Gene: 56195 Mouse Entrez Gene: 310820 Rat Omim: 608449 Human SwissProt: Q9UKA9 Human SwissProt: Q91Z31 Mouse SwissProt: Q66H20 Rat Unigene: 269895 Human Unigene: 596061 Human Unigene: 29966 Mouse Unigene: 64916 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
核糖核酸结合蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid