植烷酰辅酶A羟化酶2相互作用蛋白抗体
规格：1mg/1ml
英文名： PHYHIP
别名： DYRK1A interacting protein 3; DYRK1AP3; PAHX AP1; PAHXAP1; phytanoyl CoA 2 hydroxylase interacting protein; phytanoyl CoA alpha hydroxylase associated protein; Phytanoyl CoA hydroxylase associated pro
分子量： 38kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PHYHIP
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：
植烷酰辅酶A羟化酶2相互作用蛋白抗体产品介绍：background: PHYHIP (Phytanoyl-CoA hydroxylase-interacting protein) is a 330 amino acid protein that is strongly expressed in brain, with weak expression in ovary, small intestine and ovary. In transgenic mice, overexpression of PHYHIP in heart results in tachycardia and tachyarrhythmia. PHYHIP interacts with the Refsum disease gene product, PAHX植烷酰辅酶A羟化酶2相互作用蛋白抗体, indicating that PHYHIP may play a role in the CNS deficits of Refsum disease, which is characterized by cerebellar degeneration, neurologic damage and peripheral neuropathies. PHYHIP also interacts with Dyrk1A, a protein that that is overexpressed in brain of Down-syndrome patients, therefore PHYHIP may participate in some of the neurological abnormalities of Down syndrome. Significantly, the gene encoding PHYHIP is localized to a region of the short arm of human chromosome 8 that is frequently found deleted in prostate, breast and several other types of cancers. Function: PHYHIP interacts with PHYH, suggesting a role in the development of the central nervous system. It may be involved 植烷酰辅酶A羟化酶2相互作用蛋白抗体in the development of neurological abnormalities observed in Down syndrome patients. Subunit: Interacts with PHYH and BAI1. Subcellular Location: Protein binding Tissue Specificity: Highly expressed in the brain. Similarity: Belongs to the PHYHIP family. Contains 1 fibronectin type-III domain. Database links: UniProtKB/Swiss-Prot: Q92561.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
植烷酰辅酶A羟化酶2相互作用蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 神经生物学 结合蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid