阅读障碍相关蛋白Shootin抗体
规格：1mg/1ml
英文名： KIAA1598
别名： DKFZp686A0439; hypothetical protein FLJ11122; Kiaa1598; MGC40476; Putative uncharacterized protein KIAA1598; Shootin 1; Shootin-1; Shootin; SHOT1_HUMAN.
分子量： 72kDa
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KIAA1598
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse,
细胞定位：
阅读障碍相关蛋白Shootin抗体产品介绍：background: Shootin1 is a 631 amino acid protein that belongs to the shootin family. The shootin1 protein contains three coiled-coil domains, a proline-rich region and interacts with RUFY3. Shootin1 is involved in the generation of internal asymmetric signals required for neuronal polarization. The shootin1 protein acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. By accumulating asymmetrically in a single neurite before polarization, shootin1 leads to axon induction for阅读障碍相关蛋白Shootin抗体 polarization, additionally the absence of shootin1 from the nascent axon's siblings by competition prevents the formation of surplus axons. Existing as seven alternatively spliced isoforms, the shootin1 gene is conserved in chimpanzee, dog, mouse, rat, chicken and zebrafish, and maps to human chromosome 10q25.3. Function: Involved in the generation of internal asymmetric signals required for neuronal polarization. Acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. Accumulates asymmetrically阅读障碍相关蛋白Shootin抗体 in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons. Subunit: Interacts with RUFY3 Subcellular Location: Cell projection. Similarity: Belongs to the shootin family. Gene ID: 57698 Database links: Entrez Gene: 57698 Human Entrez Gene: 292139 Rat Omim: 611171 Human SwissProt: A0MZ66 Human SwissProt: A0MZ67 Rat Unigene: 501140 Human Unigene: 16095 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
阅读障碍相关蛋白Shootin抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid