肿瘤坏死因子受体相关蛋白3抗体
规格：1mg/1ml
英文名： TRAF3
别名： CAP 1; CAP1; CD40 associated protein 1; CD40 binding protein; CD40 bp; CD40 receptor associated factor 1; CD40bp; CRAF 1; CRAF1; LAP 1; LAP1; LMP1; Trafamn; LMP1 associated protein; MIPT3; TNF recepto
分子量： 62kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TRAF3
交叉反应：Human, Mouse, Rat,
细胞定位：
肿瘤坏死因子受体相关蛋白3抗体产品介绍：background: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and severa肿瘤坏死因子受体相关蛋白3抗体l other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq]. Function: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Seems to be involved in activation of NF-kappa-B and JNK and in apoptosis. Is regulated by TANK/ITRAF which competes with TNFRSF5/CD40 for binding. Seems to play a role T-cell dependent immune responses (By similarity). Subunit: "Homotrimer (Probable). Heteromer with TRAF5. Binds to TNFRSF5/CD40. Associates with LTBR/TNFRSF3, TNFRSF4, TNFRSF8/CD30, TNFRSF17/BCMA and EDAR, MAP3K5, MAP3K14, and TRAF-interacting protein TRIP and TRAF and TNF receptor associated protein TTRAP. Binds to TANK/ITRAF and TRAF3IP1. Interacts with TICAM1. Interacts with 肿瘤坏死因子受体相关蛋白3抗体OTUD5. Tissue Specificity: In *****, highest in brain. Also found in kidney, heart, thymus, spleen, lung, muscle, testis and ovary. Not found in liver. Similarity: Contains 1 MATH domain. Contains 1 RING-type zinc finger. Contains 2 TRAF-type zinc fingers. Gene ID: 7187 Database links: Entrez Gene: 7187 Human Entrez Gene: 22031 Mouse Entrez Gene: 362788 Rat Omim: 601896 Human SwissProt: Q13114 Human SwissProt: Q60803 Mouse Unigene: 510528 Human Unigene: 27431 Mouse Unigene: 12033 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. TRAF3是作用*为广泛的一种TRAF蛋白，它可以与LTb R、CD40、TNFRII和LMP1结合，并介导CD30、LMP1活化NF-kB。TRAF3与CD40结合后可以挽救凋亡的B细胞， TRAF3还参与CD40在B细胞中上调CD23的作用。
肿瘤坏死因子受体相关蛋白3抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 信号转导 细胞凋亡 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid