转录因子HELT蛋白抗体
规格：1mg/1ml
英文名： HELT
别名： Hairy and enhancer of split-related protein HELT; HCM1228; HELT; HELT_HUMAN; HES like ; HES/HEY like transcription factor; HES/HEY-like transcription factor; HESL; Heslike ; Hey like transcription fac
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HELT
交叉反应：Human, Mouse, Rat, Cow, Horse, Rabbit, Zebrafish, Sheep,
细胞定位：细胞核
转录因子HELT蛋白抗体产品介绍：background: The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The Notch signaling pathway is thought to maintain stem cells through transcriptional activation of HES/HEY family members to repress 转录因子HELT蛋白抗体tissue-specific transcription factors. HESL (HES-like), also known as Mgn or HELT (HES/HEY-like transcription factor), is a 327 amino acid nuclear protein belonging to the HEY family. Containing a basic helix-loop-helix (bHLH) domain and an Orange domain, HESL self-associates and interacts with HES5 and HRT2. HESL is considered a transcriptional repressor that binds to the canonical E box sequence 5'-CACGCG-3'. HESL exists as two isoforms produced by alternative splicing events. Function: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'转录因子HELT蛋白抗体-CACGCG-3'. Subunit: Self-associates. Interacts with HES5 and HEY2 Subcellular Location: Nucleus. Similarity: Belongs to the HEY family. Contains 1 basic helix-loop-helix (bHLH) domain. Contains 1 Orange domain. Database links: UniProtKB/Swiss-Prot: A6NFD8.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
转录因子HELT蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 神经生物学 信号转导 干细胞 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid