冷休克结构域蛋白C2抗体
规格：1mg/1ml
英文名： CSDC2
别名： Cold shock domain containing C2 RNA binding; Cold shock domain containing protein C2; Cold shock domain-containing protein C2; CSDC 2; Csdc2; CSDC2_HUMAN; dJ347H13.2; PIPPIN; RNA binding protein PIPPi
分子量： 17kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PIPPIN
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
冷休克结构域蛋白C2抗体产品介绍：background: PIPPIN is a Y-box protein (also called cold-shock (CSD) domain-containing protein) and belongs to a family of highly conserved RNA-binding transcriptional regulators. Predominantly expressed in brain cells and localizing to the nucleus and the cytoplasm, PIPPIN contains two RNA-binding motifs, namely PIP1 and PIP2, and one CSD domain. PIPPIN functions as a nucleic acid binding regulatory factor and is believed to participate in brain maturation. More specifically, PIPPIN binds to the 3’-UTR ends of the mRNAs encoding Histone H1 and Histone H3.3. This interaction requires all of the PIPPIN domains to work in concert as one functional protein. In addition, PIPPIN can 冷休克结构域蛋白C2抗体be sumoylated in a thyroid hormone (T3)-dependent manner. This suggests that PIPPIN modification in response to extracellular stimuli may modulate the regulation of protein synthesis. Function: RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain. Subcellular Location: Nucleus. Cytoplasm. PIPPin-RNA complexes are located to the nucleus. Similarity: Contains 1 CSD冷休克结构域蛋白C2抗体 (cold-shock) domain. Database links: Entrez Gene: 27254 Human Entrez Gene: 105859 Mouse Entrez Gene: 266600 Rat SwissProt: Q9Y534 Human SwissProt: Q91YQ3 Mouse SwissProt: Q63430 Rat Unigene: 310893 Human Unigene: 22524 Mouse Unigene: 1171 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
冷休克结构域蛋白C2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid