小脑肽1抗体
规格：1mg/1ml
英文名： CBLN1
别名： CBLN 1; Cerebellin 1; Cerebellin 1 precursor; Cerebellin1; Precerebellin; CBLN1_HUMAN.
分子量： 19kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CBLN1
交叉反应：Human, Mouse, Rat, Pig, Rabbit,
细胞定位：细胞膜 分泌型蛋白
小脑肽1抗体产品介绍：background: Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3), and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. CER and it metabolite des-Ser1-cerebellin are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing 小脑肽1抗体each other’s degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of CER has been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for CER in the pathology of these diseases. Function: CBLN1 is required for synapse integrity and synaptic plasticity. It is required for the ER export and secretion of CBLN3. CBLN1 exerts neuromodulatory functions. It directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release. Subunit: Homohexamer; disulfide-linked homotrimers. The trimers are assembled via the 小脑肽1抗体globular C1q domains. The trimers associate via N-terminal cysteine residues to form disulfide-linked hexamers. Probably forms a heteomeric complex with CBLN3. May interact with CBLN2 and CBLN4 Subcellular Location: Secreted. Membrane. Cell junction, synapse. Tissue Specificity: In the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less abundant than [des-Ser1]-cerebellin. Post-translational modifications: The proteolytic processing to yield cerebellin seems to occur either prior to the secretion by presynaptic neurons and subsequent oligomerization or in some other location after release of the mature protein. Similarity: Contains 1 C1q domain. Database links: UniProtKB/Swiss-Prot: P23435.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
小脑肽1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid