ELAVL2蛋白抗体
规格：1mg/1ml
英文名： ELAVL2
别名： ELAV like Neuronal Protein 1; ELAV like Protein 2; ELAV-like neuronal protein 1; ELAV-like protein 2; ELAV2_HUMAN; ELAVL2; HEL-N1; HELN1; HU Antigen B; Hu-antigen B; HUB; Nervous System Specific RNA B
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ELAVL2 (
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
细胞定位：
ELAVL2蛋白抗体产品介绍：background: The Elav-like genes encode for a family of RNA-binding proteins. Elav, a Drosophila protein and the first described member, is expressed immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. Several mammalian Elav-like proteins, designated HuC, HuD and Hel-N1, are also expressed in postmitotic neurons. An additional mammalian homolog, HuR, which is also designated HuA, is ubiquitously expressed and is also overexpressed in a wide variety of tumors.ELAVL2蛋白抗体 Characteristically, these homologs all contain three RNA recognition motifs (RRM) and they specifically bind to AU-rich elements (ARE) in the 3'-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation. When Elav-like proteins associate with these ARE sites this degradation is inhibited, leading to an increased stability of the corresponding transcript. Elav proteins function within the nucleus, and they are shuttled between the nucleus and cytoplasm by a nuclear export signal, which is a regulatory feature of the Elav-like proteins as it limits their accessibility to ARE sites. Function: Binds RNA. ELAVL2蛋白抗体Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR. Subunit: Interacts with IGF2BP1. Tissue Specificity: Brain; neural-specific. Similarity: Belongs to the RRM elav family. Contains 3 RRM (RNA recognition motif) domains. Database links: Entrez Gene: 1993 Human Entrez Gene: 15569 Mouse Entrez Gene: 286973 Rat Omim: 601673 Human SwissProt: Q12926 Human SwissProt: Q60899 Mouse SwissProt: Q8CH84 Rat Unigene: 166109 Human Unigene: 318042 Mouse Unigene: 12662 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ELAVL2蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid