舞蹈症蛋白相互作用蛋白13抗体
规格：1mg/1ml
英文名： HYPE
别名： HIP13; Adenosine monophosphate-protein transferase FICD; AMPylator FICD; FIC domain containing; FIC domain containing protein; FIC domain-containing protein; Fic S phase protein cell division homolog;
分子量： 52kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HYPE (16
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse, Sheep,
细胞定位：细胞膜
舞蹈症蛋白相互作用蛋白13抗体产品介绍：background: Huntingtin yeast partner E is a 458 amino acid single-pass membrane protein. HYPE is thought to interact with Huntingtin, a protein which induces neurodegeneration when mutated. HYPE also contains two tetratricopeptide repeats (TPR), which may be involved in protein-protein interaction. The gene that encodes HYPE is located on chromosome 12, which encodes over 1,100 genes within 132 million bases and makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the舞蹈症蛋白相互作用蛋白13抗体 NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy. Function: Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified. Subunit: Interacts with HD. Subcellular Location: Membrane; Single-pass membrane protein (Potential). Tissue Specificity:舞蹈症蛋白相互作用蛋白13抗体 Ubiquitous. Similarity: Belongs to the fic family. Contains 1 fido domain. Contains 2 TPR repeats. Database links: Entrez Gene: 11153 Human Entrez Gene: 231630 Mouse Entrez Gene: 288741 Rat SwissProt: Q9BVA6 Human SwissProt: Q8BIX9 Mouse SwissProt: Q6AY47 Rat Unigene: 661891 Human Unigene: 21926 Mouse Unigene: 162153 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
舞蹈症蛋白相互作用蛋白13抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 Alzheimer's
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid