肌萎缩侧索硬化症相关蛋白HECW1抗体
规格：1mg/1ml
英文名： HECW1
别名： NEDL1; C2 and WW domain-containing protein 1; E3 ubiquitin-protein ligase HECW1; HECT; HECT type E3 ubiquitin ligase; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1; HECT, C2 and WW d
分子量： 179kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
免疫原：KLH conjugated synthetic peptide derived from human HECW1 (2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow,
细胞定位：细胞浆
肌萎缩侧索硬化症相关蛋白HECW1抗体产品介绍：background: NEDL1 is a 1,606 amino acid cytoplasmic protein predominantly expressed in neurons of ***** and fetal brain. NEDL1 functions as an E3 ubiquitin-protein ligase that, characteristic of E3 ligase proteins, accepts ubiquitin (in the form of a thioester) from an E2 ubiquitin-conjugating enzyme and transfers that ubiquitin residue to substrates targeted for degradation. NEDL1 mediates ubiquitination and subsequent degradation of Dvl-1 and targets mutant SOD-1. NEDL1 forms cytotoxic aggregates with Dvl, TRAP-?and mutant SOD1 that lead to motor neuron death in FALS (familial amyotrophic lateral sclerosis). individuals affect by FALS肌萎缩侧索硬化症相关蛋白HECW1抗体 (also known as Lou Gehrig's disease) experience muscle weakness and atrophy throughout the body. FALS is caused by the degeneration of upper and lower motor neurons resulting in loss of signal to muscles. Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. Subunit: Interacts with DVL1 and SSR3.肌萎缩侧索硬化症相关蛋白HECW1抗体 Also interacts with mutant SOD1. Subcellular Location: Cytoplasm. Tissue Specificity: Predominantly expressed in neurons of ***** and fetal brain. Weakly expressed in the kidney. Similarity: Contains 1 C2 domain. Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. Contains 2 WW domains. Gene ID: 23072 Database links: Entrez Gene: 23072 Human Omim: 610384 Human SwissProt: Q76N89 Human Unigene: 164453 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肌萎缩侧索硬化症相关蛋白HECW1抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 细胞凋亡 表观遗传学 泛素
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid