膜内蛋白酶4抗体
规格：1mg/1ml
英文名： IMP4
别名： SPPL2B; IMP4; Signal peptide peptidase-like 2B; Intramembrane protease 4; Protein SPP-like 2B; SPPL2B; SPP2B_HUMAN.
分子量： 65kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SPPL2B (
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆 细胞膜
膜内蛋白酶4抗体产品介绍：background: This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: The SPPLs are a group of aspartic proteases that are 膜内蛋白酶4抗体responsible for proteolysis of type II membrane-anchored signalling factors. SPPL2b, unlike other SPPL family members is found in endosomes/lysosomes, and not the endoplasmic reticulum, and has a role in catalysing intramembrane cleavage of tumour necrosis factor alpha (TNFalpha). Subunit: Monomer. Homodimer. Interacts with ITM2B and TNF. Subcellular Location: Membrane; multi-pass membrane protein of endosomes/lysosomes. Tissue Specificity: Expressed predominantly in adrenal cortex and mammary gland. Post-translational modifications: 膜内蛋白酶4抗体Glycosylated. Similarity: Belongs to the peptidase A22B family. Contains 1 PA (protease associated) domain. Database links: Entrez Gene: 56928 Human SwissProt: Q8TCT7 Human Unigene: 330742 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
膜内蛋白酶4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 细胞粘附分子 泛素 Alzheimer's
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid