脂肪组织分化相关蛋白抗体
规格：1mg/1ml
英文名： ADFP
别名： ADFP; Adipophilin; Adipose differentiation related protein; Adipose differentiation-related protein; Perilipin-2; PLIN2; PLIN2_HUMAN; adipophilin; Adipose differentiation related protein; ADRP; MGC105
分子量： 48kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ADFP
交叉反应：Human, Mouse, Rat,
细胞定位：
脂肪组织分化相关蛋白抗体产品介绍：background: The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in 脂肪组织分化相关蛋白抗体diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011] Function: May be involved in development and maintenance of adipose tissue. Subcellular Location: Membrane; Peripheral membrane protein. Tissue Specificity: Milk lipid globules. Post-translational modifications: Acylated; primarily with C14, C16 and C18 fatty acids. Similarity: Belongs to the perilipin family. Gene ID: 123 Database links: Entrez Gene: 123 Human Entrez Gene: 11520 Mouse Entrez Gene: 298199 Rat Omim:脂肪组织分化相关蛋白抗体 103195 Human SwissProt: Q99541 Human SwissProt: P43883 Mouse Unigene: 3416 Human Unigene: 381 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Adipophilin（ADFP）是一种脂滴周围主要的相关蛋白，它大量分布在脂质蓄积正常或不正常的细胞中，是脂质蓄积的一个特异性标记物。它在脂肪细胞分化早期就有很高的表达，但当脂肪细胞成熟后，它的表达就明显减少，故称；脂肪分化相关蛋白。 ADFP在很多组织器官中都发挥重要作用，它不仅参与脂肪细胞的脂质代谢、脂滴的形成及肝内三酰甘油（TO）的合成与代谢，还能促进巨噬细胞、平滑肌细胞的泡沫化，长链脂肪酸的摄取，乳汁的分泌等。 ADFP的表达异常与动脉粥样硬化、胰岛素抵抗和肿瘤等病理过程密切相关。
脂肪组织分化相关蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 **学 信号转导 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid