磷酸肌醇相互作用蛋白抗体
规格：1mg/1ml
英文名： PIRT
别名： hCG_1776018; Phosphoinositide interacting regulator of transient receptor potential channels ; Phosphoinositide-interacting protein; Pirt; PIRT_HUMAN.
分子量： 15kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PIRT
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
磷酸肌醇相互作用蛋白抗体产品介绍：background: PIRT is a 137 amino acid multi-pass membrane protein. Highly conserved among vertebrates, PIRT consists of two transmembrane domains and one putative C-terminal phosphoinositide-binding domain. Although PIRT is expressed in peripheral nervous system, with highest levels in dorsal root ganglion and trigeminal neurons, and lowest levels in sympathetic and 磷酸肌醇相互作用蛋白抗体enteric neurons, it is not expressed in spinal cord. PIRT is a required component of the VR1 complex, which positively regulates VR1, a sensor of both noxious heat and capsaicin. Correspondingly, PIRT knockout results in impaired responses to noxious heat and capsaicin exposure, while VR1 remains unaltered. The gene that encodes PIRT maps to human chromosome 17p13.1. Function: Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol-4,5-bisphosphate (PIP2).磷酸肌醇相互作用蛋白抗体 Binds various phosphoinositide, including phosphatidylinositol-4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI). Subunit: Interacts with TRPV1 Subcellular Location: Membrane; Multi-pass membrane protein Database links: Entrez Gene: 644139 Human Omim: 612068 Human SwissProt: P0C851 Human Unigene: 553909 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸肌醇相互作用蛋白抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid