凝溶胶蛋白抗体
规格：1mg/1ml
英文名： Gelsolin
别名： Actin depolymerizing factor; ADF; AGEL; Amyloidosis Finnish type; Brevin; DKFZp313L0718; GSN; GELS_HUMAN; Actin-depolymerizing factor.
分子量： 80kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Gelsolin
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 分泌型蛋白
凝溶胶蛋白抗体产品介绍：background: Gelsolin is a calcium dependent actin binding protein. It is a potent modulator of actin filament length and gelation. Gelsolin has been shown to exist in at least two variant forms, cytoplasmic gelsolin and plasma gelsolin. Plasma gelsolin has also been called actin depolymerizing factor (ADF) or brevin. Human plasma and rabbit macrophage gelsolins differ by the presence of a 25 amino acid residue extension at the NH2 terminus in the human plasma gelsolin, which appears to account for the difference in relative molecular weights. Function: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer凝溶胶蛋白抗体 exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Subunit: Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X. Subcellular Location: Isoform 2: Cytoplasm, cytoskeleton. Isoform 1: Secreted. Tissue Specificity: Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells. Post-translational modifications: Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids. DISEASE: Amyloidosis 5 (AMYL5) [MIM:105120]: A hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of 凝溶胶蛋白抗体internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the villin/gelsolin family. Contains 6 gelsolin-like repeats. Gene ID: 2934 Database links: Entrez Gene: 2934 Human Entrez Gene: 227753 Mouse Entrez Gene: 296654 Rat Omim: 137350 Human SwissProt: P06396 Human SwissProt: P13020 Mouse SwissProt: Q68FP1 Rat Unigene: 522373 Human Unigene: 21109 Mouse Unigene: 103770 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 凝溶胶蛋白(gelsolin)是凝溶胶蛋白超家族的成员之一,是一种重要的肌动蛋白结合蛋白,其通过切断、封端肌动蛋白丝,或使肌动蛋白聚集成核等方式来控制肌动蛋白的结构. 还在细胞运动、控制细胞程序性死亡等细胞活动中发挥重要的作用.此外,凝溶胶蛋白在肿瘤细胞中的表达量也发生一定的变化. gelsolin也参与细胞调节作用。
凝溶胶蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid