γ-分泌酶组件蛋白NCLN抗体
规格：1mg/1ml
英文名： Nicalin
别名： NCLN; NCLN_HUMAN; NET59; Nicalin; Nicalin homolog (zebrafish); Nicastrin like protein; Nicastrin-like protein.
分子量： 59kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Nicalin
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 细胞膜
γ-分泌酶组件蛋白NCLN抗体产品介绍：background: Nicastrin is an integral part of the Alzheimers associated gamma-secretase complex. Nicalin, a nicastrin-like protein, is not associated with gamma-secretase but rather interacts with NOMO (Nodal modulator). Nodals are TGF beta signaling factors that control various cell fate decisions during embryonic body planning stages in vertebrate development. The Nicalin/NOMO complex acts to regulate the nodal signaling factors during gastrulation. This regulation most often affects the development of the axial mesoderm.γ-分泌酶组件蛋白NCLN抗体 Nodal signaling is an important factor for melanoma cell invasiveness and tumorigenicity and inhibition of this signal can promote melanoma cells reverting back toward a melanocyte phenotype. Function: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Subunit: Forms a complex with NOMO2 and TMEM147, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to the gamma-secretase complex. Subcellular Location: Endoplasmic reticulumγ-分泌酶组件蛋白NCLN抗体 membrane. Tissue Specificity: Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart. Similarity: Belongs to the nicastrin family. Database links: Entrez Gene: 56926 Human Entrez Gene: 103425 Mouse Entrez Gene: 314648 Rat Omim: 609156 Human SwissProt: Q969V3 Human SwissProt: Q8VCM8 Mouse SwissProt: Q5XIA1 Rat Unigene: 657032 Human Unigene: 302791 Mouse Unigene: 4202 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Nicastrin(NCT)是高度糖基化的I型跨膜蛋白,是γ-分泌酶复合物的重要组件蛋白之一,广泛分布于人类或鼠的所有细胞类型。它不仅与γ-分泌酶的组装和成熟密切相关,其构象及表达变化对γ-分泌酶活性和阿尔茨海默病(Alzheimer's disease,AD)中β淀粉样蛋白(amyloid proteinβ,Aβ)的产生及降解也起重要调节作用。
γ-分泌酶组件蛋白NCLN抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导 生长因子和** 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid