α1-chimaerin蛋白抗体
规格：1mg/1ml
英文名： Alpha chimerin
别名： CHN 1; A-chimaerin; Alpha-chimerin; Alpha chimerin; ARHGAP2; CHIN_HUMAN; CHN; Chn1; N chimaerin; N chimerin; N-chimaerin; N-chimerin; NC; Rho GTPase-activating protein 2; RHOGAP2.
分子量： 53kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Alpha-ch
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
细胞定位：
α1-chimaerin蛋白抗体产品介绍：background: This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011] Function: GTPase-activating protein for p21-rac and a phorbol ester receptor. May play an important role in neuronal signal-transduction mechanisms. Subunit: Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 α1-chimaerin蛋白抗体activation to RAC1 regulation Tissue Specificity: In neurons in brain regions that are involved in learning and memory processes. DISEASE: Defects in CHN1 are the cause of Duane retraction syndrome type 2 (DURS2) [MIM:604356]. Duane retraction syndrome is a congenital eye movement disorder characterized by a failure of cranial nerve VI (the abducens nerve) to develop normally, resulting in restriction or absence of abduction, adduction, or both, and narrowing of the palpebral fissure and retraction of the globe on attempted adduction. Undiagnosed in children, it can lead to amblyopia, a permanent uncorrectable loss of vision. Similarity: Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 Rho-GAP domain. Contains 1 α1-chimaerin蛋白抗体SH2 domain. Database links: Entrez Gene: 1123 Human Entrez Gene: 108699 Mouse Entrez Gene: 84030 Rat Omim: 118423 Human SwissProt: P15882 Human SwissProt: Q91V57 Mouse SwissProt: P30337 Rat Unigene: 380138 Human Unigene: 475464 Mouse Unigene: 11166 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
α1-chimaerin蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 G蛋白信号
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid