小脑肽3抗体
规格：1mg/1ml
英文名： CBLN3
别名： Cbln3; Cbln 3; Cbln-3; CBLN3_HUMAN; Cerebellin-3; Cerebellin3; Cerebellin 3; PRO1486.
分子量： 18kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Cerebell
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜 分泌型蛋白
小脑肽3抗体产品介绍：background: Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor called Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3) and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. Cerebellin and its metabolite, des-Ser(1)Cer, are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric 小脑肽3抗体complexes, thereby influencing each other’s degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of Cerebellin have been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for Cerebellin in the pathology of these diseases. Function: May be involved in synaptic functions in the CNS. Subunit: Heterohexamer; disulfide-linked heterotrimers. Does not homooligomerize, but probably forms a小脑肽3抗体 complex with at least CBLN1. May interact with CBLN2 and CBLN4 Subcellular Location: Secreted. Cell junction, synapse (By similarity). Note=Secretion depends probably on a association with CBLN1 or perhaps CBLN4 but not on CBLN2 Similarity: Contains 1 C1q domain. Database links: Entrez Gene: 643866 Human Entrez Gene: 56410 Mouse Omim: 612978 Human SwissProt: Q6UW01 Human SwissProt: Q9JHG0 Mouse Unigene: 207603 Human Unigene: 97163 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
小脑肽3抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid