毒蕈碱型乙酰胆碱受体M1抗体
规格：1mg/1ml
英文名： muscarinic Acetylcholine Receptor 1
别名： muscarinic acetylcholine receptor; M-AChR M1; Muscarinic Acetylcholine Receptor 1;cholinergic receptor, muscarinic 1; Chrm1; Chrm-1; M1; M1R; Muscarinic Acetylcholine receptor M1; Cholinergic receptor
分子量： 51kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human muscarin
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse,
细胞定位：细胞膜
毒蕈碱型乙酰胆碱受体M1抗体产品介绍：background: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq毒蕈碱型乙酰胆碱受体M1抗体, Jul 2008]. Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Subunit: Interacts with GPRASP2. Subcellular Location: Cell membrane; Multi-pass membrane protein. 毒蕈碱型乙酰胆碱受体M1抗体Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily. Gene ID: 1128 Database links: Entrez Gene: 1128 Human Entrez Gene: 12669 Mouse Entrez Gene: 25229 Rat Omim: 118510 Human SwissProt: P11229 Human SwissProt: P12657 Mouse SwissProt: P08482 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. AChR M1 毒蕈碱型乙酰胆碱受体M1,属于G蛋白偶联受体家族成员，主要分布于**神经系统和周围神经系统，乙酰胆碱与受体结合后诱导其功能：抑制酰苷酸环化酶、降解磷酸肌醇、膜钾离子通道开放.
毒蕈碱型乙酰胆碱受体M1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 细胞膜受体 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid