神经突起生长诱导因子受体UNC5B抗体
规格：1mg/1ml
英文名： UNC5C
别名： UNC5H3; Alternative nameshomolog of C. elegans transmembrane receptor Unc5; Netrin receptor UNC5C; Protein unc 5 homolog C; Unc 5 homolog 3; Unc 5 homolog C; Unc5 (C.elegans homolog) c; UNC5H3; UNC5C_
分子量： 99kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human UNC5H3
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 1
细胞定位：细胞膜
神经突起生长诱导因子受体UNC5B抗体产品介绍：background: This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008] Function: UNC5C is a receptor for netrin required for axon guidance. It mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It is also involved in corticospinal tract axon guidances independently of DCC. 神经突起生长诱导因子受体UNC5B抗体It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. There are two named isoforms. Subunit: Interacts with the cytoplasmic part of DCC Subcellular Location: Membrane; Single-pass type I membrane protein Tissue Specificity: Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or ***** lung. Post-translational modifications: Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine phosphorylation is netrin-dependent (By similarity). Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to神经突起生长诱导因子受体UNC5B抗体 induce apoptosis Similarity: Belongs to the unc-5 family. Contains 1 death domain. Contains 1 Ig-like (immunoglobulin-like) domain. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 2 TSP type-1 domains. Contains 1 ZU5 domain. Database links: Entrez Gene: 8633 Human Entrez Gene: 22253 Mouse Entrez Gene: 362049 Rat Omim: 603610 Human SwissProt: O95185 Human SwissProt: O08747 Mouse SwissProt: Q761X5 Rat Unigene: 388565 Human Unigene: 24430 Mouse Unigene: 47255 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
神经突起生长诱导因子受体UNC5B抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid