组织因子途径抑制剂-2抗体
规格：1mg/1ml
英文名： TFPI-2
别名： tissue factor pathway inhibitor 2; TFPI-2; TFPI2; TFPI2_HUMAN; Tissue factor pathway inhibitor 2; Placental protein 5; PP5; TFPI 2; TFPI 2; TFPI2 PEN.
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TFPI2
交叉反应：Human, Mouse, Rat, Cow,
细胞定位：细胞外基质 分泌型蛋白
组织因子途径抑制剂-2抗体产品介绍：background: TFPI2 may play a role in the regulation of plasmin-mediated matrix remodeling. It inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa, but it has no effect on thrombin. TFPI2 is specific to umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. This inhibitor contains three inhibitory domains. TFPI2 contains 3 BPTI/Kunitz inhibitor domains. Function: May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, 组织因子途径抑制剂-2抗体plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin. Subcellular Location: Secreted (constituent of proteinaceous extracellular matrix) Tissue Specificity: Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. Similarity: Contains 3 BPTI/Kunitz inhibitor domains. Gene ID: 7980 Database links: Entrez Gene: 7980 Human Omim: 600033 Human SwissProt: P48307 Human Unigene: 438231 Human Important Note: This product as supplied is intended for research use only, not for use 组织因子途径抑制剂-2抗体in human, therapeutic or diagnostic applications. 组织因子途径抑制因子(tissue factor pathway in hibitor, TFPI)是组织因子凝血途径的主要抑制因子， 组织因子途径抑制因子在诸如动脉粥样硬化，血管再狭窄，弥漫性血管内凝血DIC等方面，有一定的研究价值。 TFPI-2也称为胎盘蛋白-5(placenta protein 5，PP5)或细胞基质联合丝氨酸蛋白酶抑制物(matrix associated serine protease inhibitor，MSPI)。 TFPI-2是相对分子质量为:25KDa的丝氨酸蛋白酶抑制物, 由脉管系统细胞（内皮细胞、平滑肌细胞、成纤维细胞）合成，并沉积在这些细胞的细胞外基质里。TFPI-2为广谱丝氨酸蛋白酶抑制剂，能有效地抑制基质金属蛋白酶（MMP）、纤溶酶、胰蛋白酶、糜蛋白酶、组织蛋白酶等多种蛋白水解酶的活性，在维持细胞外基质（ECM）结构完整、抑制肿瘤细胞浸润转移方面起着重要作用。TFPI-2分布广泛,在人肝脏、肾脏、心脏、骨骼肌等正常组织中有着高度表达,而在肿瘤组织中也有一定程度的表达。
组织因子途径抑制剂-2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid