神经颗粒素抗体
规格：1mg/1ml
英文名： Neurogranin
别名： Calmodulin binding protein; Hng; NEUG(55-78); NEUG_HUMAN; Neurogranin (protein kinase C substrate); Ng; NG; NRGN; Protein kinase C substrate; RC3; BICKS.
分子量： 7.6kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NG/Neuro
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：
神经颗粒素抗体产品介绍：background: Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in ***** subjects. [provided by RefSeq, Jul 2008]. Function: Acts as a "third messenger"神经颗粒素抗体 substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium. Tissue Specificity: In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease. Post-translational modifications: Phosphorylated at Ser-36 by PHK Similarity: Belongs to the neurogranin family. Contains 1 collagen-like domain. Contains 1 IQ domain. Database links: Entrez Gene: 616955 Cow 神经颗粒素抗体Entrez Gene: 4900 Human Entrez Gene: 64011 Mouse Entrez Gene: 64356 Rat Omim: 602350 Human SwissProt: P35722 Cow SwissProt: Q92686 Human SwissProt: P60761 Mouse SwissProt: Q04940 Rat Unigene: 524116 Human Unigene: 335065 Mouse Unigene: 11236 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
神经颗粒素抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid