褐黑素相关蛋白ART抗体
规格：1mg/1ml
英文名： AGRP
别名： Agouti Related Protein Homolog; agouti signaling protein; agouti switch protein; Agouti-related protein; Agrp; AGRP_HUMAN; AGRT; ART; ASIP2.
分子量： 12kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human AGRP (31
交叉反应：Human,
细胞定位：细胞浆 分泌型蛋白
褐黑素相关蛋白ART抗体产品介绍：background: This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. Function: Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R褐黑素相关蛋白ART抗体 endocytosis in an arrestin-dependent manner. Subunit: Interacts with melanocortin receptors MC3R, MC4R and MC5R. Subcellular Location: Secreted. Golgi apparatus lumen. Tissue Specificity: Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney. DISEASE: Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:601665]褐黑素相关蛋白ART抗体. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Similarity: Contains 1 agouti domain. Database links: UniProtKB/Swiss-Prot: O00253.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
褐黑素相关蛋白ART抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid