跨膜硫酸软骨素蛋白聚糖C抗体
规格：1mg/1ml
英文名： Neuroglycan C
别名： Acidic leucine rich EGF like domain containing brain protein; Acidic leucine-rich EGF-like domain-containing brain protein; Caleb; CSPG5_HUMAN.
分子量： 57kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Neurogly
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
细胞定位：细胞浆 细胞膜
跨膜硫酸软骨素蛋白聚糖C抗体产品介绍：background: Neuroglycan C is a brain-specific chondroitin sulfate proteoglycan (CSPG) implicated in the proliferation of neural stem and progenitor cells. Neuro-glycan C is a single-pass membrane protein that can manifest as a part-time proteoglycan depending on the tissue expressing it. In its proteoglycan form, Neuroglycan C exhibits chondroitin sulfate glycans and functions as a receptor for midkine, a growth factor that binds heparin, to affect cytoskeletal changes. By means of ectodomain shedding, the ectodomain of Neuroglycan C is able to enhance neurite outgrowth from neurons. Neurite growth stimulation is affected by both an EGF-like and an acidic amino acid domain found on the shed ectodomain. Both domains instigate neurite growth, however, these domains exhibit differing 跨膜硫酸软骨素蛋白聚糖C抗体functionality as to number of neurites produced and neuron types stimulated. Function: May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. Subunit: Binds TNR and probably TNC (By similarity). Interacts with ERBB3 and GOPC. Subcellular Location: Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus membrane. In neurons, localizes to synaptic junctions (By similarity). Also detected in the endoplasmic reticulum and the Golgi (By similarity). Partially enriched in lipid rafts. Tissue Specificity: Restricted to brain (at protein level). Post-translational modifications: O-glycosylated; contains chondroitin sulfate glycans. Part-time proteoglycan, expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form. The relative amount of both f跨膜硫酸软骨素蛋白聚糖C抗体orms depends on tissues and tissues maturation. Phosphorylated; in intracellular and extracellular parts. Similarity: Contains 1 EGF-like domain. Gene ID: 10675 Database links: Entrez Gene: 10675 Human Entrez Gene: 29873 Mouse Entrez Gene: 50568 Rat Omim: 606775 Human SwissProt: O95196 Human SwissProt: Q49AA8 Human SwissProt: Q71M36 Mouse SwissProt: Q9ERQ6 Rat Unigene: 45127 Human Unigene: 38496 Mouse Unigene: 10146 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
跨膜硫酸软骨素蛋白聚糖C抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 干细胞 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid