热休克蛋白70相互作用蛋白抗体
规格：1mg/1ml
英文名： HSPABP/HIP/HSC70 Interacting Protein HIP
别名： AAG 2; AAG2; Aging associated protein 2; F10A1_HUMAN; FAM10A1; FAM10A4; FLJ27260; Heat shock 70kD protein binding protein; HIP; HOP; Hsc70 interacting protein; Hsc70-interacting protein; Hsp70 interac
分子量： 41kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HSPABP
交叉反应：Human,
细胞定位：细胞浆
热休克蛋白70相互作用蛋白抗体产品介绍：background: Hip (HSP70-interacting protein), also known as ST13 (suppression of tumorigenicity protein 13), is one of several co-chaperones that regulate activities of the HSP70 chaperone family (1,2). The homo-oligomeric protein Hip cooperates with HSP70 in protein folding by stabilizing the ADP-bound state of HSP70. Hip directly binds to the ATPase domain of HSP70 when it is converted to the ADP-bound state by proteins of the HSP40 family (3). By collaborating with other positive co-factors such as HSP40 and Hop, or competing with negative co-factors such as Bag1, Hip may facilitate the chaperone function of HSP70 in protein folding and repair, and in controlling 热休克蛋白70相互作用蛋白抗体the activity of regulatory proteins such as steroid receptors and various regulators of proliferation or apoptosis (4-8). Function: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins. Subunit: Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90 (By similarity). Interacts (via the C-terminus 303- 319 AA) with GRK5. Subcellular Location: Cytoplasm. Similarity: Belongs to the FAM10 family. Contains 1 STI1 domain.热休克蛋白70相互作用蛋白抗体 Contains 3 TPR repeats. Database links: Entrez Gene: 281506 Cow Entrez Gene: 6767 Human Entrez Gene: 70356 Mouse Entrez Gene: 81800 Rat Omim: 606796 Human SwissProt: P50502 Human SwissProt: Q99L47 Mouse SwissProt: P50503 Rat Unigene: 712713 Human Unigene: 180337 Mouse Unigene: 119613 Rat Unigene: 8796 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
热休克蛋白70相互作用蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid