蛋白转运抑制剂GBF1抗体
规格：1mg/1ml
英文名： GBF1
别名： ARF1GEF; BFA resistant GEF 1; BFA-resistant GEF 1; FLJ21263; FLJ21500; GBF1; GBF1_HUMAN; Golgi specific brefeldin A resistance factor 1; Golgi specific Brefeldin A-resistance factor; Golgi-specific br
分子量： 206kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Brefeldi
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：
蛋白转运抑制剂GBF1抗体产品介绍：background: Protein trafficking to the membrane requires formation of coated carrier vesicles, such as COPI-coated vesicles from the cis-golgi, a process triggered by membrane binding of the GTP-bound form of ADP-ribosylation factors. Normally, brefeldin A (BFA) blocks this action by inhibiting guanine nucleotide exchange factors (GEFs) for ADP-ribosylation factor. However, GBF1, a member of the sec7-domain family of GEFs, allows cells to maintain normal golgi morphology and grow in the presence of BFA.蛋白转运抑制剂GBF1抗体 The gene encoding the human GBF1 protein maps to chromosome 10q24, with the sec7-domain centrally positioned, and a proline-rich C-terminus. Based on mutatagenesis analysis, this proline rich region appears to interact with p115 in a functionally significant manner. Function: Promotes guanine-nucleotide exchange on ARF5. Promotes the activation of ARF5 through replacement of GDP with GTP. Tissue 蛋白转运抑制剂GBF1抗体Specificity: Ubiquitous. Similarity: Contains 1 SEC7 domain. Database links: Entrez Gene: 8729 Human Entrez Gene: 107338 Mouse Omim: 603698 Human SwissProt: Q92538 Human Unigene: 290243 Human Unigene: 271620 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白转运抑制剂GBF1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid