系统性红斑狼疮相关蛋白TREX1抗体
规格：1mg/1ml
英文名： TREX1
别名： ATRIP; AGS 1; AGS1; AGS-1; Aicardi Goutieres syndrome 1; ATIP; ATM and Rad3 related interacting protein; ATM and Rad3-related-interacting protein; ATR interacting protein; ATR-interacting protein; Atr
分子量： 87kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ATRIP(15
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
细胞定位：细胞核
系统性红斑狼疮相关蛋白TREX1抗体产品介绍：background: DNA damage or incomplete replication of DNA results in the inhibition of cell cycle progression at the G1 to S or the G2 to M phase transition by conserved regulatory mechanisms known as cell cycle checkpoints. Checkpoint proteins include Rad17, which is involved in regulating cell cycle progression at the G1 checkpoint as well as Chk1, Chk2, Rad1, Rad9 and Hus1, which are involved in regulating cell cycle arrest at the G2 checkpoint. In response to DNA damage, ATM and ATR kinases are important for cell cycle checkpoint response signalling. ATR-interacting protein (ATRIP), also designated ATM and Rad3-related-interacting protein,系统性红斑狼疮相关蛋白TREX1抗体 is required for checkpoint signaling after DNA damage. It is also important for ATR expression, which regulates DNA replication and damage checkpoint responses. ATRIP is a ubiquitously expressed protein that can form heterodimers with ATR. After dimerization they bind the RPA complex and are recruited to single stranded DNA. ATRIP is a nuclear protein that may also play a role in protein stabilization. Function: Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. Subunit: Interacts with ATR. Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single stranded DNA. Interacts with CEP164 系统性红斑狼疮相关蛋白TREX1抗体(via N-terminus). Interacts with CINP. Subcellular Location: Nucleus. Redistributes to discrete nuclear foci upon DNA damage. Tissue Specificity: Ubiquitous. Post-translational modifications: Phosphorylated by ATR. Similarity: Belongs to the ATRIP family. Database links: Entrez Gene: 11277 Human Entrez Gene: 22040 Mouse Entrez Gene: 100049583 Rat Omim: 606609 Human SwissProt: Q9NSU2 Human SwissProt: Q91XB0 Mouse Unigene: 707026 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
系统性红斑狼疮相关蛋白TREX1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid